Mouse Interferon regulatory factor 1 ELISA Kit | Irf1 elisa kit

Mouse Interferon regulatory factor 1 ELISA Kit

Cat. Num. AAA2885817

• Gene Names: Irf1; Irf-1; AU020929
• Reactivity: Mouse
• Synonyms: Interferon regulatory factor 1; Mouse Interferon regulatory factor 1 ELISA Kit; IRF-1; Irf1; Irf1 elisa kit

• Reactivity: Mouse
• Sequence Length: 329

• Assay Type: Sandwich
• Detection Range: 31.2-2000 pg/mL
• Sensitivity: 15.7 pg/mL
• Intra-Assay CV: <=8.2%
• Inter-Assay CV: <=10.1%
• Recovery: 86%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 226874846
• NCBI GeneID: 16362
• NCBI Accession #: NP_001152868.1
• NCBI GenBank Nucleotide #: NM_001159396.1
• UniProt Accession #: P15314
• Molecular Weight: 37,319 Da
• NCBI Official Full Name: interferon regulatory factor 1 isoform a
• NCBI Official Synonym Full Names: interferon regulatory factor 1
• NCBI Official Symbol: Irf1
• NCBI Official Synonym Symbols: Irf-1; AU020929
• NCBI Protein Information: interferon regulatory factor 1
• UniProt Protein Name: Interferon regulatory factor 1
• Protein Family: Interferon regulatory factor
• UniProt Gene Name: Irf1
• UniProt Synonym Gene Names: IRF-1
• UniProt Entry Name: IRF1_MOUSE

Uniprot Description

Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity are: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.