Typical Testing Data/Standard Curve (for reference only)
Mouse Presenilin-2 ELISA Kit | Psen2 elisa kit
Mouse Presenilin-2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]
Uniprot Description
PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Protease; EC 3.4.23.-; Cell surface
Cellular Component: apical plasma membrane; cell cortex; cell soma; centrosome; cytosol; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; kinetochore; membrane; nuclear inner membrane; nucleus; perinuclear region of cytoplasm; protein complex; Z disc
Molecular Function: aspartic endopeptidase activity, intramembrane cleaving; aspartic-type endopeptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; protein binding
Biological Process: alveolus development; amyloid precursor protein catabolic process; anagen; beta-amyloid metabolic process; brain morphogenesis; calcium ion transport; cardiac muscle contraction; cell fate specification; cellular protein metabolic process; dorsoventral neural tube patterning; embryonic development; embryonic limb morphogenesis; endoplasmic reticulum calcium ion homeostasis; forebrain development; hair follicle development; hemopoietic progenitor cell differentiation; learning and/or memory; locomotion; membrane protein ectodomain proteolysis; memory; myeloid leukocyte differentiation; negative regulation of epidermal growth factor receptor activity; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; positive regulation of coagulation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of receptor recycling; protein maturation; protein processing; protein transport; proteolysis; regulation of epidermal growth factor receptor activity; regulation of protein binding; regulation of synaptic plasticity; skin morphogenesis; somitogenesis; T cell activation during immune response; T cell receptor signaling pathway; thymus development
Research Articles on Psen2
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Product Notes
The Mouse Psen2 psen2 (Catalog #AAA2880898) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880898 ELISA Kit recognizes Mouse Psen2. It is sometimes possible for the material contained within the vial of "Presenilin-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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