Human Tissue factor pathway inhibitor ELISA Kit | TFPI elisa kit
Human Tissue factor pathway inhibitor ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
Uniprot Description
TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Membrane protein, GPI anchor; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 2q32
Cellular Component: cell surface; endoplasmic reticulum; extracellular region; extracellular space; plasma membrane
Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: blood coagulation; blood coagulation, extrinsic pathway