Mouse Antizyme inhibitor 2 ELISA Kit | Adc elisa kit

Mouse Antizyme inhibitor 2 ELISA Kit

Cat. Num. AAA2884294

• Gene Names: Azin2; Adc; Azi2; Odcp; ODC-p; B930082O19; 4933429I20Rik
• Reactivity: Mouse
• Synonyms: Antizyme inhibitor 2; Mouse Antizyme inhibitor 2 ELISA Kit; AZI2; Arginine decarboxylase-like protein; ADC; ARGDC; Adc; Adc elisa kit

• Reactivity: Mouse
• Sequence Length: 459

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 27370330
• NCBI GeneID: 242669
• NCBI Accession #: NP_766463.1
• NCBI GenBank Nucleotide #: NM_172875.4
• UniProt Accession #: Q8BVM4; A2A823
• Molecular Weight: 49,503 Da
• NCBI Official Full Name: antizyme inhibitor 2 isoform 1
• NCBI Official Synonym Full Names: antizyme inhibitor 2
• NCBI Official Symbol: Azin2
• NCBI Official Synonym Symbols: Adc; Azi2; Odcp; ODC-p; B930082O19; 4933429I20Rik
• NCBI Protein Information: antizyme inhibitor 2
• UniProt Protein Name: Antizyme inhibitor 2
• Protein Family: Antizyme inhibitor
• UniProt Gene Name: Azin2
• UniProt Synonym Gene Names: Adc; Odcp; AzI2; ADC; ARGDC; ODC-like protein; ODC-p
• UniProt Entry Name: AZIN2_MOUSE

NCBI Description

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

ADC: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Belongs to the Orn/Lys/Arg decarboxylase class-II family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; Amino Acid Metabolism - arginine and proline; EC 4.1.1.19; Mitochondrial

Cellular Component: axon; cell projection; cis-Golgi network; cytoplasm; cytoplasmic vesicle; dendrite; ER-Golgi intermediate compartment membrane; Golgi apparatus; membrane; mitochondrion; nucleus; perikaryon; perinuclear region of cytoplasm; trans-Golgi network; transport vesicle

Molecular Function: arginine decarboxylase activity; catalytic activity; ornithine decarboxylase activator activity; ornithine decarboxylase activity; protein binding; putrescine transmembrane transporter activity

Biological Process: negative regulation of protein catabolic process; ornithine metabolic process; polyamine biosynthetic process; positive regulation of catalytic activity; putrescine biosynthetic process from ornithine; putrescine transport; transport