Rat C-C chemokine receptor type 5 ELISA Kit | Ccr5 elisa kit

Rat C-C chemokine receptor type 5 ELISA Kit

Cat. Num. AAA2883993

• Gene Names: Ccr5; Ckr5; Cmkbr5
• Reactivity: Rat
• Synonyms: C-C chemokine receptor type 5; Rat C-C chemokine receptor type 5 ELISA Kit; C-C CKR-5; CC-CKR-5; CCR-5; MIP-1 alpha receptor; Ccr5; Cmkbr5; CD195; Ccr5 elisa kit

• Reactivity: Rat
• Sequence Length: 354

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.156 ng/mL
• Intra-Assay CV: <=4.7%
• Inter-Assay CV: <=8.2%
• Recovery: 100%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 51592090
• NCBI GeneID: 117029
• NCBI Accession #: NP_446412.2
• NCBI GenBank Nucleotide #: NM_053960.3
• UniProt Accession #: O08556
• Molecular Weight: 41,031 Da
• NCBI Official Full Name: C-C chemokine receptor type 5
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 5
• NCBI Official Symbol: Ccr5
• NCBI Official Synonym Symbols: Ckr5; Cmkbr5
• NCBI Protein Information: C-C chemokine receptor type 5
• UniProt Protein Name: C-C chemokine receptor type 5
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: Ccr5
• UniProt Synonym Gene Names: Cmkbr5; C-C CKR-5; CC-CKR-5; CCR-5
• UniProt Entry Name: CCR5_RAT

NCBI Description

G protein-coupled receptor; involved in regulation of leukocyte activation and migration [RGD, Feb 2006]

Uniprot Description

CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Receptor, cytokine; Receptor, GPCR

Cellular Component: cell surface; cytoplasm; cytosol; endosome; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; CCR2 chemokine receptor binding; glycoprotein binding; protein binding; protein kinase binding

Biological Process: aging; calcium ion transport; calcium-mediated signaling; cell-cell signaling; chemotaxis; defense response; defense response to bacterium; elevation of cytosolic calcium ion concentration; fat cell differentiation; forebrain development; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; leukocyte migration; MAPKKK cascade; negative regulation of axon extension; negative regulation of cell migration; positive regulation of apoptosis by virus; positive regulation of cell-cell adhesion; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to ionizing radiation; response to lipopolysaccharide