Typical Testing Data/Standard Curve (for reference only)
Rat Cholesterol side-chain cleavage enzyme, mitochondrial ELISA Kit | Cyp11a1 elisa kit
Rat Cholesterol side-chain cleavage enzyme, mitochondrial ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
monooxygenase that catalyzes synthesis of cholesterol and steroids [RGD, Feb 2006]
Uniprot Description
CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family.
Protein type: Oxidoreductase; EC 1.14.15.6; Lipid Metabolism - C21-steroid hormone; Mitochondrial
Cellular Component: mitochondrial crista; mitochondrial inner membrane; mitochondrion; perikaryon
Molecular Function: cholesterol binding; cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
Biological Process: biphenyl metabolic process; C21-steroid hormone biosynthetic process; cerebellum development; cholesterol metabolic process; dibenzo-p-dioxin metabolic process; glucocorticoid biosynthetic process; granulosa cell differentiation; hippocampus development; Leydig cell differentiation; male gonad development; maternal process involved in pregnancy; mating behavior; organic acid metabolic process; phenol metabolic process; phthalate metabolic process; response to alkaloid; response to amino acid stimulus; response to antibiotic; response to cadmium ion; response to cAMP; response to corticosterone stimulus; response to drug; response to estrogen stimulus; response to gamma radiation; response to genistein; response to hydrogen peroxide; response to insecticide; response to ionizing radiation; response to L-ascorbic acid; response to nutrient; response to organic cyclic substance; response to organic substance; response to peptide hormone stimulus; response to salt stress; response to steroid hormone stimulus; response to vitamin E; Schwann cell differentiation; steroid biosynthetic process
Research Articles on Cyp11a1
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Product Notes
The Rat Cyp11a1 cyp11a1 (Catalog #AAA2881132) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881132 ELISA Kit recognizes Rat Cyp11a1. It is sometimes possible for the material contained within the vial of "Cholesterol side-chain cleavage enzyme, mitochondrial, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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