Mouse Interleukin-6 receptor subunit alpha ELISA Kit | Il6ra elisa kit
Mouse Interleukin-6 receptor subunit alpha ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: apical plasma membrane; cell surface; extracellular region; extracellular space; integral to membrane; interleukin-6 receptor complex; membrane
Molecular Function: ciliary neurotrophic factor receptor activity; enzyme binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; protein homodimerization activity
Biological Process: cell growth; cytokine and chemokine mediated signaling pathway; developmental growth; endocrine pancreas development; negative regulation of collagen biosynthetic process; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; positive regulation of MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; response to cytokine stimulus