Human Thioredoxin-interacting protein ELISA Kit | TXNIP elisa kit

Human Thioredoxin-interacting protein ELISA Kit

Cat. Num. AAA2880674

• Gene Names: TXNIP; THIF; VDUP1; HHCPA78; EST01027
• Reactivity: Human
• Synonyms: Thioredoxin-interacting protein; Human Thioredoxin-interacting protein ELISA Kit; Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1; TXNIP; VDUP1; TXNIP elisa kit

• Reactivity: Human
• Sequence Length: 336

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.039 ng/mL
• Intra-Assay CV: <=5.6%
• Inter-Assay CV: <=8.8%
• Recovery: 101%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 928192549
• NCBI GeneID: 10628
• NCBI Accession #: NP_001300901.1
• NCBI GenBank Nucleotide #: NM_001313972.1
• UniProt Accession #: Q9H3M7; Q16226; Q6PML0; Q9BXG9; B4E3D3
• Molecular Weight: 37,319 Da
• NCBI Official Full Name: thioredoxin-interacting protein isoform 2
• NCBI Official Synonym Full Names: thioredoxin interacting protein
• NCBI Official Symbol: TXNIP
• NCBI Official Synonym Symbols: THIF; VDUP1; HHCPA78; EST01027
• NCBI Protein Information: thioredoxin-interacting protein
• UniProt Protein Name: Thioredoxin-interacting protein
• Protein Family: Thioredoxin-interacting protein
• UniProt Gene Name: TXNIP
• UniProt Synonym Gene Names: VDUP1
• UniProt Entry Name: TXNIP_HUMAN

NCBI Description

This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Description

TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor; Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: cytoplasm; cytosol; mitochondrial intermembrane space; nucleus

Molecular Function: enzyme inhibitor activity; protein binding; ubiquitin protein ligase binding

Biological Process: cell cycle; innate immune response; keratinocyte differentiation; negative regulation of catalytic activity; negative regulation of cell division; negative regulation of transcription from RNA polymerase II promoter; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; protein import into nucleus; regulation of cell proliferation; response to calcium ion; response to drug; response to estradiol stimulus; response to glucose stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to progesterone stimulus; transcription, DNA-dependent