Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 ELISA Kit | HCN1 elisa kit
Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) ELISA Kit
Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate HCN1 in Human serum, plasma. An antibody specific for HCN1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any HCN1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for HCN1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of HCN1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI and Uniprot Product Information
NCBI Description
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Uniprot Description
HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5p12
Cellular Component: axon; dendrite; integral component of plasma membrane; plasma membrane
Molecular Function: cAMP binding; identical protein binding; intracellular cAMP activated cation channel activity; potassium channel activity; voltage-gated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process: apical protein localization; protein homotetramerization; regulation of membrane potential; regulation of postsynaptic membrane potential; retinal cone cell development
Disease: Epileptic Encephalopathy, Early Infantile, 24
Research Articles on HCN1
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Product Notes
The Human HCN1 hcn1 (Catalog #AAA280311) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA280311 ELISA Kit recognizes Human HCN1. It is sometimes possible for the material contained within the vial of "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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