Rabbit TGF-beta receptor type-1 ELISA Kit | TGFBR1 elisa kit
Rabbit TGF-beta receptor type-1 (TGFBR1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Description
TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: cell surface; lipid raft; plasma membrane; receptor complex; tight junction
Molecular Function: ATP binding; growth factor binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; punt binding; receptor signaling protein activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I
Biological Process: activation of MAPKK activity; activin receptor signaling pathway; anterior/posterior pattern formation; artery morphogenesis; cell cycle arrest; cell motility involved in cell locomotion; collagen fibril organization; embryonic cranial skeleton morphogenesis; endothelial cell activation; epithelial to mesenchymal transition; extracellular structure organization and biogenesis; germ cell migration; heart development; in utero embryonic development; kidney development; mesenchymal cell differentiation; negative regulation of chondrocyte differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; palate development; parathyroid gland development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; regulation of protein ubiquitination; regulation of transcription, DNA-dependent; signal transduction; skeletal development; skeletal morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway; wound healing
Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
Research Articles on TGFBR1
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Product Notes
The Rabbit TGFBR1 tgfbr1 (Catalog #AAA2606164) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2606164 ELISA Kit recognizes Rabbit TGFBR1. It is sometimes possible for the material contained within the vial of "TGF-beta receptor type-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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