Alpha-1-antitrypsin 1-1/Serpin A1e Recombinant Protein | A1e recombinant protein

Recombinant Mouse Alpha-1-antitrypsin 1-1/Serpin A1e (C-6His)

Cat. Num. AAA2569321

• Gene Names: Serpina1e; PI5; Dom5; Spi1-5
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Alpha-1-antitrypsin 1-1/Serpin A1e; Recombinant Mouse Alpha-1-antitrypsin 1-1/Serpin A1e (C-6His); Alpha-1-antitrypsin 1-5; Alpha-1 protease inhibitor 5; Serine protease inhibitor 1-5; Serine protease inhibitor A1e; Serpin A1e; Serpina1e; Dom5; Spi1-5; A1e recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Supplied as a 0.2um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH8.0.
• Sequence: Glu25-Lys413

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Serpin A1e is produced by our Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.; This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20 degree C.

SDS-Page

Related Product Information for A1e recombinant protein

Alpha-1-antitrypsin 1-5 (SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 6678087
• NCBI GeneID: 20704
• NCBI Accession #: NP_033273.1
• NCBI GenBank Nucleotide #: NM_009247.2
• UniProt Accession #: Q00898; Q3UJ83; Q545P1
• Molecular Weight: 45,891 Da
• NCBI Official Full Name: alpha-1-antitrypsin 1-5
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade A, member 1E
• NCBI Official Symbol: Serpina1e
• NCBI Official Synonym Symbols: PI5; Dom5; Spi1-5
• NCBI Protein Information: alpha-1-antitrypsin 1-5
• UniProt Protein Name: Alpha-1-antitrypsin 1-5
• UniProt Gene Name: Serpina1e
• UniProt Synonym Gene Names: Dom5; Spi1-5; Serpin A1e
• UniProt Entry Name: A1AT5_MOUSE

Uniprot Description

Serpina1e: Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. Belongs to the serpin family.

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protease binding; protease inhibitor activity; endopeptidase inhibitor activity; glycoprotein binding

Biological Process: response to peptide hormone stimulus; response to cytokine stimulus; negative regulation of peptidase activity