Rabbit anti-Human, Mouse KCNA10 Polyclonal Antibody | anti-KCNA10 antibody

KCNA10 Polyclonal Antibody

Cat. Num. AAA2561723

• Gene Names: KCNA10; Kcn1; Kv1.8
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: KCNA10; Polyclonal Antibody; KCNA10 Polyclonal Antibody; Cyclic GMP gated potassium channel; KCA10; Kcn 1; Kcn1; KCNA 10; Kv1.8; Potassium voltage gated channel shaker related subfamily member 10; Potassium voltage gated channel subfamily A member 10; Potassium voltage-gated channel subfamily A member 10; Voltage gated potassium channel subunit Kv1.8; Voltage-gated potassium channel subunit Kv1.8; anti-KCNA10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.72mg/mL (varies by lot)
• Sequence Length: 511

• Applicable Applications for anti-KCNA10 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:40-1:200; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human KCNA10
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using KCNA10 Polyclonal Antibody at dilution of 1:40(×200))

Related Product Information for anti-KCNA10 antibody

KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA4.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.

Product Categories/Family for anti-KCNA10 antibody

Cancer; Metabolism; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 5031819
• NCBI GeneID: 3744
• NCBI Accession #: NP_005540.1
• NCBI GenBank Nucleotide #: NP_005540.1
• UniProt Accession #: Q16322
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 10
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily A member 10
• NCBI Official Symbol: KCNA10
• NCBI Official Synonym Symbols: Kcn1; Kv1.8
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 10
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 10
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA10

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNA10: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: integral component of membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: intracellular cyclic nucleotide activated cation channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; protein homooligomerization