Rabbit CC2D1A Polyclonal Antibody | anti-CC2D1A antibody

CC2D1A Polyclonal Antibody

Cat. Num. AAA2561558

• Gene Names: CC2D1A; MRT3; FREUD-1; Freud-1/Aki1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: CC2D1A; Polyclonal Antibody; CC2D1A Polyclonal Antibody; Akt kinase interacting protein 1; Coiled coil and C2 domain containing 1A; Coiled coil and C2 domain containing protein 1A; Five repressor element under dual repression binding protein 1; FLJ20241; FLJ41160; FRE under dual repression binding protein 1; FREUD 1; Freud 1/Aki1; Mental retardation; nonsyndromic; autosomal recessive; 3; MRT3; Putative NF kappa B activating protein 023N; Putative NF kappa B activating protein; anti-CC2D1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 951

• Applicable Applications for anti-CC2D1A antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:30-1:150; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human CC2D1A
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CC2D1A Polyclonal Antibody at dilution of 1:35(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using CC2D1A Polyclonal Antibody at dilution of 1:35(×200))

Related Product Information for anti-CC2D1A antibody

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Product Categories/Family for anti-CC2D1A antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 74737148
• NCBI GeneID: 54862
• UniProt Accession #: Q6P1N0
• NCBI Official Full Name: Coiled-coil and C2 domain-containing protein 1A
• NCBI Official Synonym Full Names: coiled-coil and C2 domain containing 1A
• NCBI Official Symbol: CC2D1A
• NCBI Official Synonym Symbols: MRT3; FREUD-1; Freud-1/Aki1
• NCBI Protein Information: coiled-coil and C2 domain-containing protein 1A
• UniProt Protein Name: Coiled-coil and C2 domain-containing protein 1A
• Protein Family: Coiled-coil and C2 domain-containing protein
• UniProt Gene Name: CC2D1A
• UniProt Synonym Gene Names: AKI1; FRE under dual repression-binding protein 1; Freud-1
• UniProt Entry Name: C2D1A_HUMAN

NCBI Description

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]

Uniprot Description

CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function: signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Disease: Mental Retardation, Autosomal Recessive 3