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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ADRM1 Polyclonal Antibody at dilution of 1:70(×200))

Rabbit ADRM1 Polyclonal Antibody | anti-ADRM1 antibody

ADRM1 Polyclonal Antibody

Gene Names
ADRM1; ARM1; ARM-1; GP110
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, ELISA
Purity
Antigen Affinity Purification
Synonyms
ADRM1; Polyclonal Antibody; ADRM1 Polyclonal Antibody; 110 kDa cell membrane glycoprotein; Adhesion regulating molecule 1; Adhesion-regulating molecule 1; ADRM 1; Adrm1; ARM 1; ARM-1; ARM1; Gp110; HRpn13; M(r) 110; 000 surface antigen; Proteasomal ubiquitin receptor ADRM1; Proteasome regulatory particle non ATPase 13; Proteasome regulatory particle non-ATPase 13; Regulatory particle non ATPase 13; Rpn13; Rpn13 homolog; anti-ADRM1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Form/Format
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Concentration
1.26mg/mL (varies by lot)
Sequence Length
407
Applicable Applications for anti-ADRM1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
IHC: 1:50-1:300
ELISA: 1:5000-1:10000
Immunogen
Fusion protein of human ADRM1
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ADRM1 Polyclonal Antibody at dilution of 1:70(×200))

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ADRM1 Polyclonal Antibody at dilution of 1:70(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using ADRM1 Polyclonal Antibody at dilution of 1:70(×200))

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using ADRM1 Polyclonal Antibody at dilution of 1:70(×200))
Related Product Information for anti-ADRM1 antibody
The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.
Product Categories/Family for anti-ADRM1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Proteasomal ubiquitin receptor ADRM1
NCBI Official Synonym Full Names
adhesion regulating molecule 1
NCBI Official Symbol
ADRM1
NCBI Official Synonym Symbols
ARM1; ARM-1; GP110
NCBI Protein Information
proteasomal ubiquitin receptor ADRM1
UniProt Protein Name
Proteasomal ubiquitin receptor ADRM1
UniProt Gene Name
ADRM1
UniProt Synonym Gene Names
GP110; Gp110; ARM-1; hRpn13
UniProt Entry Name
ADRM1_HUMAN

NCBI Description

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.

Protein type: Proteasome complex; Cell development/differentiation

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: proteasome complex; nucleoplasm; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; protease binding

Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly

Research Articles on ADRM1

Similar Products

Product Notes

The ADRM1 adrm1 (Catalog #AAA2560717) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRM1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ADRM1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:50-1:300 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the ADRM1 adrm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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