CTLA-4/CD152 active protein
Recombinant Cavia Porcellus CTLA-4/CD152 Protein (C-His)
Purity
>90% as determined by reducing SDS-PAGE.
Synonyms
CTLA-4/CD152; Recombinant Cavia Porcellus CTLA-4/CD152 Protein (C-His); Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4; CTLA-4/CD152 active protein
Host
P. Pichia
Purity/Purification
>90% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of PBS, pH7.4.
Sequence
Ala37-Asp161
Species
Cavia Porcellus
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Fusion Tag
C-His
Activity
Measured by its ability to bind Human B7-1 in functional ELISA. The ED50 for this effect is 0.05-0.5ug/ml
Preparation and Storage
Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.
Related Product Information for CTLA-4/CD152 active protein
Protein Construction: Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.
Background: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Background: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
NCBI and Uniprot Product Information
UniProt Accession #
Molecular Weight
Molecular Mass: 14.1kDa
Actual Protein Molecular Mass: 18-40kDa
Actual Protein Molecular Mass: 18-40kDa
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Product Notes
The CTLA-4/CD152 (Catalog #AAA2557623) is an Active Protein produced from P. Pichia and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Ala37-Asp1 61. It is sometimes possible for the material contained within the vial of "CTLA-4/CD152, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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