Serpin A3N Recombinant Protein | Serpina3n recombinant protein
Recombinant Mouse Serpin A3N Protein (C-His)
Gene Names
Serpina3n; Spi2-2; Spi2.2; Spi2/eb.4
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Serpin A3N; Recombinant Mouse Serpin A3N Protein (C-His); Serine protease inhibitor A3N; Serpina3n; Spi2; Serpina3n recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
Sequence
Phe21-Lys418
Sequence Length
418
Species
Mouse
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Fusion Tag
C-His
Preparation and Storage
Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.
Related Product Information for Serpina3n recombinant protein
Protein Construction: Recombinant Mouse Serpin A3N is produced by our mammalian expression system and the target gene encoding Phe21-Lys418 is expressed with a 6His tag at the C-terminus.
Background: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to alpha1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.
Background: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to alpha1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
Molecular Mass: 45.6kDa
Actual Protein Molecular Mass: 58kDa
Actual Protein Molecular Mass: 58kDa
NCBI Official Full Name
Serine protease inhibitor A3N
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade A, member 3N
NCBI Official Symbol
Serpina3n
NCBI Official Synonym Symbols
Spi2-2; Spi2.2; Spi2/eb.4
NCBI Protein Information
serine protease inhibitor A3N
UniProt Protein Name
Serine protease inhibitor A3N
Protein Family
UniProt Gene Name
Serpina3n
UniProt Synonym Gene Names
Spi2; Serpin A3N
UniProt Entry Name
SPA3N_MOUSE
Uniprot Description
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular region; extracellular space
Molecular Function: protease inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: acute-phase response; negative regulation of peptidase activity; response to cytokine stimulus; response to peptide hormone stimulus
Research Articles on Serpina3n
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Product Notes
The Serpina3n serpina3n (Catalog #AAA2557444) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Phe21-Lys4 18. It is sometimes possible for the material contained within the vial of "Serpin A3N, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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