IL-1R8/IL1RAPL1 recombinant protein

Recombinant Human IL-1R8/IL1RAPL1 Protein (C-His)

Cat. Num. AAA2557243

• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL-1R8/IL1RAPL1; Recombinant Human IL-1R8/IL1RAPL1 Protein (C-His); Interleukin-1 Receptor Accessory Protein-Like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; Oligophrenin-4; Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 2; TIGIRR-2; X-Linked Interleukin-1 Receptor Accessory Protein-Like 1; IL1RAPL1; OPHN4; IL-1R8/IL1RAPL1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Leu19-Thr357
• Sequence Length: 696

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-1R8/IL1RAPL1 recombinant protein

Protein Construction: Recombinant Human IL-1R8 is produced by our mammalian expression system and the target gene encoding Leu19-Thr357 is expressed with a 6His tag at the C-terminus.

Background: Interleukin-1 receptor accessory protein-like 1, also known as IL1RAPL1, can be detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. IL1RAPL1 functions as a homodimer, it interacts with NCS1, PTPRD. This interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation. During dendritic spine formation, it can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.

NCBI and Uniprot Product Information

• NCBI GI #: 34222654
• UniProt Accession #: Q9NZN1
• Molecular Weight: Molecular Mass: 40kDa; Actual Protein Molecular Mass: 50-70kDa
• NCBI Official Full Name: Interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• UniProt Gene Name: IL1RAPL1
• UniProt Synonym Gene Names: OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2
• UniProt Entry Name: IRPL1_HUMAN

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22.1-p21.3

Cellular Component: postsynaptic membrane; cell surface; axon; cytoplasm; dendrite; plasma membrane; integral to membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding

Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction

Disease: Mental Retardation, X-linked 21