Thrombopoietin/THPO/TPO Recombinant Protein | THPO/TPO recombinant protein

Recombinant Mouse Thrombopoietin/THPO/TPO Protein (N-6His)

Cat. Num. AAA2553624

• Gene Names: Thpo; Ml; Tpo; Mgdf; Mpllg
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Thrombopoietin/THPO/TPO; Recombinant Mouse Thrombopoietin/THPO/TPO Protein (N-6His); Thrombopoietin; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Myeloproliferative leukemia virus oncogene ligand; THPO; THPO/TPO recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Ser22-Thr356
• Sequence Length: 356

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for THPO/TPO recombinant protein

Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

NCBI and Uniprot Product Information

• NCBI GI #: 291045237
• NCBI GeneID: 21832
• NCBI Accession #: NP_001166976.1
• NCBI GenBank Nucleotide #: NM_001173505.1
• UniProt Accession #: P40226
• Molecular Weight: Molecular Mass: 36.4 kDa; Actual Protein Molecular Mass: 80-110 kDa
• NCBI Official Full Name: thrombopoietin isoform 1
• NCBI Official Synonym Full Names: thrombopoietin
• NCBI Official Symbol: Thpo
• NCBI Official Synonym Symbols: Ml; Tpo; Mgdf; Mpllg
• NCBI Protein Information: thrombopoietin
• UniProt Protein Name: Thrombopoietin
• UniProt Gene Name: Thpo
• UniProt Synonym Gene Names: ML; MGDF

NCBI Description

This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.