beta-Defensin 4A Recombinant Protein | DEFB4B recombinant protein

Recombinant Human beta-Defensin 4A Protein

Cat. Num. AAA2553423

• Gene Names: DEFB4B; DEFB4P
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: beta-Defensin 4A; Recombinant Human beta-Defensin 4A Protein; Beta-Defensin 4A; Beta-Defensin 2; BD-2; hBD-2; Defensin; Beta 2; Skin-Antimicrobial Peptide 1; SAP1; DEFB4A; DEFB102; DEFB2; DEFB4; DEFB4B; DEFB4B recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 130mM NaCl, pH 7.4.
• Sequence Positions: Gly24-Pro64
• Sequence Length: 64

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for DEFB4B recombinant protein

beta-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 beta-Defensins, which are distinguished from alpha-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. beta-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 327532771
• NCBI GeneID: 100289462
• NCBI Accession #: NP_001192195.1
• NCBI GenBank Nucleotide #: NM_001205266.1
• UniProt Accession #: O15263; Q52LC0
• Molecular Weight: Molecular Mass: 4.3 kDa; Actual Protein Molecular Mass: 9 kDa
• NCBI Official Full Name: beta-defensin 4B
• NCBI Official Synonym Full Names: defensin beta 4B
• NCBI Official Symbol: DEFB4B
• NCBI Official Synonym Symbols: DEFB4P
• NCBI Protein Information: beta-defensin 4B
• UniProt Protein Name: Beta-defensin 4A
• Protein Family: Beta-defensin
• UniProt Gene Name: DEFB4A
• UniProt Synonym Gene Names: DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1

NCBI Description

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]

Uniprot Description

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).