TRAIL R3/TNFRSF10C/CD263 recombinant protein

Recombinant Human TRAIL R3/TNFRSF10C/CD263 Protein (C-6His)

Cat. Num. AAA2553298

• Gene Names: TNFRSF10C; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: TRAIL R3/TNFRSF10C/CD263; Recombinant Human TRAIL R3/TNFRSF10C/CD263 Protein (C-6His); Tumor Necrosis Factor Receptor Superfamily Member 10C; Antagonist Decoy Receptor for TRAIL/Apo-2L; Decoy TRAIL Receptor Without Death Domain; Decoy Receptor 1; DcR1; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand Receptor 3; TRAIL Receptor 3; TRAIL-R3; TRAIL Receptor Without an Intracellular Domain; CD263; TNFRSF10C; DCR1; LIT; TRAILR3; TRID; TRAIL R3/TNFRSF10C/CD263 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Positions: Ala26-Ala221
• Sequence Length: 259

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for TRAIL R3/TNFRSF10C/CD263 recombinant protein

Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn't transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 22547121
• NCBI GeneID: 8794
• NCBI Accession #: NP_003832.2
• NCBI GenBank Nucleotide #: NM_003841.4
• UniProt Accession #: O14798; O14755; Q08AS6; Q6FH98; Q6UXM5
• Molecular Weight: Molecular Mass: 21.8 kDa; Actual Protein Molecular Mass: 40 kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10C
• NCBI Official Synonym Full Names: TNF receptor superfamily member 10c
• NCBI Official Symbol: TNFRSF10C
• NCBI Official Synonym Symbols: LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10C
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10C
• UniProt Gene Name: TNFRSF10C
• UniProt Synonym Gene Names: DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.