Plasma Kallikrein/KLKB1 Recombinant Protein | KLKB1 recombinant protein

Recombinant Human Plasma Kallikrein/KLKB1 Protein (C-6His)

Cat. Num. AAA2553095

• Gene Names: KLKB1; PKK; PPK; KLK3; PKKD
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Plasma Kallikrein/KLKB1; Recombinant Human Plasma Kallikrein/KLKB1 Protein (C-6His); Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein; KLKB1; KLK3; KLKB1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
• Sequence Positions: Gly20-Ala638
• Sequence Length: 638

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for KLKB1 recombinant protein

KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

NCBI and Uniprot Product Information

• NCBI GI #: 78191798
• NCBI GeneID: 3818
• NCBI Accession #: NP_000883.2
• NCBI GenBank Nucleotide #: NM_000892.4
• UniProt Accession #: P03952; Q17RE8; Q17RE9; Q4W5C3; A6NH96; B2R8H9
• Molecular Weight: Molecular Mass: 70.2 kDa; Actual Protein Molecular Mass: 75-87 kDa
• NCBI Official Full Name: plasma kallikrein isoform 1 preproprotein
• NCBI Official Synonym Full Names: kallikrein B1
• NCBI Official Symbol: KLKB1
• NCBI Official Synonym Symbols: PKK; PPK; KLK3; PKKD
• NCBI Protein Information: plasma kallikrein
• UniProt Protein Name: Plasma kallikrein
• Protein Family: Plasma kallikrein
• UniProt Gene Name: KLKB1
• UniProt Synonym Gene Names: KLK3; PKK

NCBI Description

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.