Early Growth Response Protein 1/EGR1/ZNF225 Recombinant Protein | EGR1/ZNF225 recombinant protein

Recombinant Human Early Growth Response Protein 1/EGR1/ZNF225 Protein (N-6His)

Cat. Num. AAA2552608

• Gene Names: EGR1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Early Growth Response Protein 1/EGR1/ZNF225; Recombinant Human Early Growth Response Protein 1/EGR1/ZNF225 Protein (N-6His); EGR-1; Early growth response protein 1; Zif268; zinc finger protein 225; NGFI-A; nerve growth factor-induced protein A; EGR1/ZNF225 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Gln282-Ser433
• Sequence Length: 543

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EGR1/ZNF225 recombinant protein

EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of synaptobrevin II (a protein important for synaptic exocytosis).

NCBI and Uniprot Product Information

• NCBI GI #: 4503493
• NCBI GeneID: 1958
• NCBI Accession #: NP_001955.1
• NCBI GenBank Nucleotide #: NM_001964.2
• UniProt Accession #: P18146
• Molecular Weight: Molecular Mass: 19.9 kDa; Actual Protein Molecular Mass: 18 kDa
• NCBI Official Full Name: early growth response protein 1
• NCBI Official Synonym Full Names: early growth response 1
• NCBI Official Symbol: EGR1
• NCBI Official Synonym Symbols: TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268
• NCBI Protein Information: early growth response protein 1
• UniProt Protein Name: Early growth response protein 1
• UniProt Gene Name: EGR1
• UniProt Synonym Gene Names: KROX24; ZNF2251 PublicationManual assertion based on opinion iniRef.3; EGR-11 PublicationManual assertion based on opinion iniRef.1; NGFI-A

NCBI Description

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

Uniprot Description

Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary ().