Chloride Intracellular Channel Protein 2/CLIC2 Recombinant Protein | CLIC2 recombinant protein
Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 Protein (N-6His)
Gene Names
CLIC2; CLIC2b; MRXS32; XAP121
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Chloride Intracellular Channel Protein 2/CLIC2; Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 Protein (N-6His); Chloride Intracellular Channel Protein 2; XAP121; CLIC2; CLIC2 recombinant protein
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 100mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0.
Sequence Positions
Met1-Ser247
Sequence Length
247
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
N-6His
Preparation and Storage
Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Related Product Information for CLIC2 recombinant protein
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 30.5 kDa
Actual Protein Molecular Mass: 32 kDa
Actual Protein Molecular Mass: 32 kDa
NCBI Official Full Name
chloride intracellular channel protein 2
NCBI Official Synonym Full Names
chloride intracellular channel 2
NCBI Official Symbol
CLIC2
NCBI Official Synonym Symbols
CLIC2b; MRXS32; XAP121
NCBI Protein Information
chloride intracellular channel protein 2
UniProt Protein Name
Chloride intracellular channel protein 2
Protein Family
UniProt Gene Name
CLIC2
NCBI Description
This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Uniprot Description
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Research Articles on CLIC2
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Product Notes
The CLIC2 clic2 (Catalog #AAA2552499) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met1-Ser247. It is sometimes possible for the material contained within the vial of "Chloride Intracellular Channel Protein 2/CLIC2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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