CD79B/B29 recombinant protein

Recombinant Human CD79B/B29 Protein (C-6His)

Cat. Num. AAA2552480

• Gene Names: CD79B; B29; IGB; AGM6
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: CD79B/B29; Recombinant Human CD79B/B29 Protein (C-6His); B-Cell Antigen Receptor Complex-Associated Protein Beta Chain; B-Cell-Specific Glycoprotein B29; Ig-Beta; Immunoglobulin-Associated B29 Protein; CD79b; CD79B; B29; IGB; CD79B/B29 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Ala29-Asp159
• Sequence Length: 229

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD79B/B29 recombinant protein

CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR), which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79B enhances phosphorylation of CD79A, possibly by recruiting kinases that phosphorylate CD79A or by recruiting proteins that bind to CD79A and protect it from dephosphorylation.

NCBI and Uniprot Product Information

• NCBI GI #: 11038674
• NCBI GeneID: 974
• NCBI Accession #: NP_000617.1
• NCBI GenBank Nucleotide #: NM_000626.3
• UniProt Accession #: P40259; Q53FS2; Q9BU06
• Molecular Weight: Molecular Mass: 16.3 kDa; Actual Protein Molecular Mass: 25-36 kDa
• NCBI Official Full Name: B-cell antigen receptor complex-associated protein beta chain isoform 1
• NCBI Official Synonym Full Names: CD79b molecule
• NCBI Official Symbol: CD79B
• NCBI Official Synonym Symbols: B29; IGB; AGM6
• NCBI Protein Information: B-cell antigen receptor complex-associated protein beta chain
• UniProt Protein Name: B-cell antigen receptor complex-associated protein beta chain
• UniProt Gene Name: CD79B
• UniProt Synonym Gene Names: B29; IGB

NCBI Description

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.