Mouse anti-Human SMYD3 Monoclonal Antibody | anti-SMYD3 antibody
SMYD3 Monoclonal Antibody
IHC: 1:50-1:500
NCBI and Uniprot Product Information
Observed Molecular Weight: 49kDa
NCBI Description
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
SMYD3: Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 1q44
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: histone-lysine N-methyltransferase activity; metal ion binding; protein binding
Biological Process: establishment of protein localization; myotube cell development; negative regulation of protein kinase activity; nucleosome assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter