SerpinF1 / PEDF Recombinant Protein | PEDF recombinant protein
Rat SerpinF1 / PEDF Protein (His Tag)
Gene Names
Serpinf1; Pedf; Dmrs91
Purity
> 90 % as determined by SDS-PAGE.
Synonyms
SerpinF1 / PEDF; Rat SerpinF1 / PEDF Protein (His Tag); Dmrs91; PEDF recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
418
Application Notes
The recombinant rat Serpinf1 consists 410 amino acids and predicts a molecular mass of 45.9 kDa.
Predicted N Terminal
Gln 20
Endotoxin
< 1.0 EU per mug protein as determined by the LAL method.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for PEDF recombinant protein
Background: Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
Description: A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
pigment epithelium-derived factor
NCBI Official Synonym Full Names
serpin family F member 1
NCBI Official Symbol
Serpinf1
NCBI Official Synonym Symbols
Pedf; Dmrs91
NCBI Protein Information
pigment epithelium-derived factor
NCBI Description
mouse homolog is a proteinase inhibitor involved in vascularization [RGD, Feb 2006]
Research Articles on PEDF
Similar Products
Product Notes
The PEDF (Catalog #AAA2547277) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat Serpinf1 consists 410 amino acids and predicts a molecular mass of 45.9 kDa. Researchers should empirically determine the suitability of the PEDF for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinF1 / PEDF, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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