SDS-PAGE
CDNF / ARMETL1 recombinant protein
Recombinant Mouse CDNF / ARMETL1 Protein (His tag)
Gene Names
Cdnf; Armetl1; 9330140G23
Purity
> 95 % as determined by SDS-PAGE
Synonyms
CDNF / ARMETL1; Recombinant Mouse CDNF / ARMETL1 Protein (His tag); Cdnf; RP24-129J15.1; 9330140G23; Armetl1; MGC129430; CDNF / ARMETL1 recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
187
Application Notes
The secreted recombinant mouse CDNF consists of 174 amino acids and migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions as predicted.
Predicted N Terminal
Gln 25
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CDNF / ARMETL1 recombinant protein
Background: Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
Description: A DNA sequence encoding the mouse CDNF (NP_808315.1) (Met 1-Leu 187) was expressed, with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the mouse CDNF (NP_808315.1) (Met 1-Leu 187) was expressed, with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
21,032 Da
NCBI Official Full Name
cerebral dopamine neurotrophic factor
NCBI Official Synonym Full Names
cerebral dopamine neurotrophic factor
NCBI Official Symbol
Cdnf
NCBI Official Synonym Symbols
Armetl1; 9330140G23
NCBI Protein Information
cerebral dopamine neurotrophic factor
UniProt Protein Name
Cerebral dopamine neurotrophic factor
UniProt Gene Name
Cdnf
UniProt Synonym Gene Names
Armetl1
Uniprot Description
ARMETL1: Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Belongs to the ARMET family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2|2 A1
Cellular Component: endoplasmic reticulum; extracellular space
Biological Process: neurite development
Research Articles on CDNF / ARMETL1
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Product Notes
The CDNF / ARMETL1 cdnf (Catalog #AAA2546910) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse CDNF consists of 174 amino acids and migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions as predicted. Researchers should empirically determine the suitability of the CDNF / ARMETL1 cdnf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDNF / ARMETL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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