CEACAM1 / CD66a recombinant protein
Recombinant Mouse CEACAM1 / CD66a Protein (His tag)
Description: A DNA sequence encoding the extracellular domain of mouse CEACAM1 (NP_001034274.1) (Met 1-Gly 428) was expressed, with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
Uniprot Description
CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7 A3|7 13.84 cM
Cellular Component: adherens junction; brush border membrane; cell junction; cell surface; external side of plasma membrane; extracellular space; integral to membrane; intercellular junction; membrane; plasma membrane; T cell receptor complex
Molecular Function: actin binding; bile acid transmembrane transporter activity; calmodulin binding; filamin binding; granulocyte colony-stimulating factor receptor binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; viral receptor activity; virion binding
Biological Process: blood vessel development; calcium-dependent cell-cell adhesion; calcium-independent cell-cell adhesion; entry of virus into host cell; homophilic cell adhesion; intercellular junction assembly and maintenance; negative regulation of bone resorption; negative regulation of cytokine production; negative regulation of granulocyte differentiation; negative regulation of interleukin-1 production; negative regulation of interleukin-2 production; negative regulation of JNK cascade; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of osteoclast differentiation; negative regulation of protein kinase activity; negative regulation of T cell proliferation; negative regulation of vascular permeability; Peyer's patch development; positive regulation of immunoglobulin secretion; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of NFAT protein import into nucleus; positive regulation of T cell proliferation; regulation of endothelial cell differentiation; regulation of epidermal growth factor receptor signaling pathway
Research Articles on CEACAM1 / CD66a
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Product Notes
The CEACAM1 / CD66a ceacam1 (Catalog #AAA2546909) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse CEACAM1 consists of 405 amino acids and has a predicted molecular mass of 45 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCEACAM1 is approximately 70-100 kDa due to high glycosylation. Researchers should empirically determine the suitability of the CEACAM1 / CD66a ceacam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CEACAM1 / CD66a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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