SDS-PAGE
E-Selectin / CD62e / SELE Recombinant Protein | SELE recombinant protein
Recombinant Mouse E-Selectin / CD62e / SELE Protein
Gene Names
Sele; Elam; CD62E; ELAM-1; LECAM2; E-selectin
Purity
> 90 % as determined by SDS-PAGE
Synonyms
E-Selectin / CD62e / SELE; Recombinant Mouse E-Selectin / CD62e / SELE Protein; SELE; SELE recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
619
Application Notes
The recombinant mouse SELE comprises 543 amino acids and has a predicted molecular mass of 59.3 kDa. The apparent molecular mass of the protein is approximately 70 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Trp 29
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for SELE recombinant protein
Background: E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.
Description: A DNA sequence encoding the mouse SELE (NP_035475.1) (Met1-Pro564) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Description: A DNA sequence encoding the mouse SELE (NP_035475.1) (Met1-Pro564) was expressed with six amino acids (LEVLFQ) at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
66,750 Da
NCBI Official Full Name
E-selectin
NCBI Official Synonym Full Names
selectin, endothelial cell
NCBI Official Symbol
Sele
NCBI Official Synonym Symbols
Elam; CD62E; ELAM-1; LECAM2; E-selectin
NCBI Protein Information
E-selectin
UniProt Protein Name
E-selectin
Protein Family
UniProt Gene Name
Sele
UniProt Synonym Gene Names
Elam-1; ELAM-1; LECAM2
Uniprot Description
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1 H2.2|1 71.35 cM
Cellular Component: caveola; coated pit; cortical cytoskeleton; extracellular space; lipid raft; perinuclear region of cytoplasm
Molecular Function: phospholipase binding; sialic acid binding; transmembrane receptor activity
Biological Process: actin filament-based process; heterophilic cell adhesion; inflammatory response; leukocyte adhesion; leukocyte tethering or rolling; phospholipase C activation; positive regulation of leukocyte migration; positive regulation of receptor internalization
Research Articles on SELE
Similar Products
Product Notes
The SELE sele (Catalog #AAA2546810) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse SELE comprises 543 amino acids and has a predicted molecular mass of 59.3 kDa. The apparent molecular mass of the protein is approximately 70 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the SELE sele for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E-Selectin / CD62e / SELE, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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