FDPS recombinant protein

Recombinant Human FDPS Protein (His tag)

Gene Names

FDPS; FPS; FPPS; POROK9

Purity

> 85 % as determined by SDS-PAGE

Synonyms

FDPS; Recombinant Human FDPS Protein (His tag); FPPS; FPS; FDPS recombinant protein

Ordering
Cat. Num. AAA2545359 For Research Use Only!

Host

E Coli

Purity/Purification

> 85 % as determined by SDS-PAGE

Form/Format

Lyophilized from sterile PBS, pH 7.5

Sequence Length

353

Application Notes

The recombinant human FDPS consisting of 368 amino acids and has a calculated molecular mass of 42.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.

Predicted N Terminal

Met

Preparation and Storage

Samples are stable for up to twelve months from date of receipt at -70 degree C

Related Product Information for FDPS recombinant protein

Background: Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.

Description: A DNA sequence encoding the human FDPS isoform b (NP_001129294.1) (Met 1-Lys 353) was expressed, with a polyhistide tag at the N-terminus.

NCBI and Uniprot Product Information

NCBI GI #

209571584

NCBI GeneID

2224

NCBI Accession #

NP_001129294.1

NCBI GenBank Nucleotide #

NM_001135822.1

UniProt Accession #

P14324; Q96G29; D3DV91; E9PCI9

Molecular Weight

40,532 Da

NCBI Official Full Name

farnesyl pyrophosphate synthase isoform b

NCBI Official Synonym Full Names

farnesyl diphosphate synthase

NCBI Official Symbol

FDPS

NCBI Official Synonym Symbols

FPS; FPPS; POROK9

NCBI Protein Information

farnesyl pyrophosphate synthase

UniProt Protein Name

Farnesyl pyrophosphate synthase

Protein Family

Farnesyl pyrophosphate synthase

UniProt Gene Name

FDPS

UniProt Synonym Gene Names

FPS; KIAA1293; FPP synthase; FPS

NCBI Description

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Uniprot Description

FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.

Protein type: EC 2.5.1.1; EC 2.5.1.10; Motility/polarity/chemotaxis; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process

Disease: Porokeratosis 9, Multiple Types

Research Articles on FDPS

1. These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.

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Product Notes

The FDPS fdps (Catalog #AAA2545359) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human FDPS consisting of 368 amino acids and has a calculated molecular mass of 42.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the FDPS fdps for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FDPS, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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