Rabbit anti-Mouse CLEC10A  Monoclonal Antibody | anti-CLEC10A  antibody

Rabbit anti Mouse CLEC10A  Monoclonal Antibody

Cat. Num. AAA2544650

• Gene Names: CLEC10A; HML; MGL; HML2; CD301; CLECSF13; CLECSF14
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CLEC10A ; Monoclonal Antibody; Rabbit anti Mouse CLEC10A Monoclonal Antibody; anti-CLEC10A antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 289

• Applicable Applications for anti-CLEC10A antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CLEC10A/MGL1/CD301.
• Immunogen: Recombinant Mouse CLEC10A/MGL1/CD301 Protein
• Buffer: 0.2 mum filtered solution in PBS
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CLEC10A  antibody

CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.

NCBI and Uniprot Product Information

• NCBI GI #: 1052292322
• NCBI GeneID: 10462
• NCBI GenBank Nucleotide #: NM_001330070.1
• Molecular Weight: 28,877 Da
• NCBI Official Full Name: C-type lectin domain family 10 member A isoform 3
• NCBI Official Synonym Full Names: C-type lectin domain family 10 member A
• NCBI Official Symbol: CLEC10A
• NCBI Official Synonym Symbols: HML; MGL; HML2; CD301; CLECSF13; CLECSF14
• NCBI Protein Information: C-type lectin domain family 10 member A
• UniProt Protein Name: C-type lectin domain family 10 member A
• UniProt Gene Name: CLEC10A
• UniProt Synonym Gene Names: CLECSF13; CLECSF14; HML
• UniProt Entry Name: CLC10_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CLEC10A: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: plasma membrane