Rabbit anti-Mouse CLEC14A  Monoclonal Antibody | anti-CLEC14A  antibody

Rabbit anti Mouse CLEC14A  Monoclonal Antibody

Cat. Num. AAA2544544

• Gene Names: CLEC14A; CEG1; EGFR-5; C14orf27
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CLEC14A ; Monoclonal Antibody; Rabbit anti Mouse CLEC14A Monoclonal Antibody; anti-CLEC14A antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 490

• Applicable Applications for anti-CLEC14A antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CLEC14A. The detection limit for Mouse CLEC14A is approximately 0.078 ng/well.
• Immunogen: Recombinant Mouse CLEC14A protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CLEC14A  antibody

C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a 459 amino acid single-pass type I membrane protein. The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop ('loop-in-a-loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. Members of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates.

NCBI and Uniprot Product Information

• NCBI GI #: 28269707
• NCBI GeneID: 161198
• NCBI GenBank Nucleotide #: NM_175060.2
• Molecular Weight: 51,636 Da
• NCBI Official Full Name: C-type lectin domain family 14 member A
• NCBI Official Synonym Full Names: C-type lectin domain family 14 member A
• NCBI Official Symbol: CLEC14A
• NCBI Official Synonym Symbols: CEG1; EGFR-5; C14orf27
• NCBI Protein Information: C-type lectin domain family 14 member A
• UniProt Protein Name: C-type lectin domain family 14 member A
• UniProt Gene Name: CLEC14A
• UniProt Synonym Gene Names: C14orf27; EGFR5; EGFR-5
• UniProt Entry Name: CLC14_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

Uniprot Description

CLEC14A:

Protein type: Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: external side of plasma membrane; extracellular matrix