Rabbit anti-Mouse FGFRL1/FGFR5  Monoclonal Antibody | anti-FGFRL1/FGFR5  antibody

Rabbit anti Mouse FGFRL1/FGFR5  Monoclonal Antibody

Cat. Num. AAA2544507

• Gene Names: FGFRL1; FHFR; FGFR5
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: FGFRL1/FGFR5 ; Monoclonal Antibody; Rabbit anti Mouse FGFRL1/FGFR5 Monoclonal Antibody; anti-FGFRL1/FGFR5 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 504

• Applicable Applications for anti-FGFRL1/FGFR5 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse FGFRL1. The detection limit for Mouse FGFRL1 is approximately 0.00975 ng/well.
• Immunogen: Recombinant Mouse FGFRL1/FGFR5 Protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FGFRL1/FGFR5 (rM FGFRL1/FGFR5; NP_473412.1; Met 1-Pro 374).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 51988914
• NCBI GeneID: 53834
• NCBI GenBank Nucleotide #: NM_001004358.1
• Molecular Weight: 54,537 Da
• NCBI Official Full Name: fibroblast growth factor receptor-like 1
• NCBI Official Synonym Full Names: fibroblast growth factor receptor-like 1
• NCBI Official Symbol: FGFRL1
• NCBI Official Synonym Symbols: FHFR; FGFR5
• NCBI Protein Information: fibroblast growth factor receptor-like 1
• UniProt Protein Name: Fibroblast growth factor receptor-like 1
• UniProt Gene Name: FGFRL1
• UniProt Synonym Gene Names: FGFR5; FHFR; FGF receptor-like protein 1; FGFR-5
• UniProt Entry Name: FGRL1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FGFRL1: Has a negative effect on cell proliferation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: Golgi apparatus; plasma membrane; transport vesicle

Molecular Function: fibroblast growth factor receptor activity; heparin binding

Biological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerization

Disease: Wolf-hirschhorn Syndrome