Rabbit anti-Human FGF14  Monoclonal Antibody | anti-FGF14  antibody

Rabbit anti Human FGF14  Monoclonal Antibody

Cat. Num. AAA2544421

• Gene Names: FGF14; FHF4; FHF-4; SCA27; FGF-14
• Reactivity: Human
• Applications: ELISA
• Synonyms: FGF14 ; Monoclonal Antibody; Rabbit anti Human FGF14 Monoclonal Antibody; anti-FGF14 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 187

• Applicable Applications for anti-FGF14 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human FGF14/SCA27. The detection limit for Human FGF14/SCA27 is approximately 0.0195 ng/well.
• Immunogen: Recombinant Human FGF14/SCA27 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-FGF14  antibody

FGF14 is a member of the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 is probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). It is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia. It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

NCBI and Uniprot Product Information

• NCBI GI #: 1013165743
• NCBI GeneID: 2259
• NCBI GenBank Nucleotide #: NM_001321938.1
• Molecular Weight: 28,462 Da
• NCBI Official Full Name: fibroblast growth factor 14 isoform 5
• NCBI Official Synonym Full Names: fibroblast growth factor 14
• NCBI Official Symbol: FGF14
• NCBI Official Synonym Symbols: FHF4; FHF-4; SCA27; FGF-14
• NCBI Protein Information: fibroblast growth factor 14
• UniProt Protein Name: Fibroblast growth factor 14
• UniProt Gene Name: FGF14
• UniProt Synonym Gene Names: FHF4; FGF-14; FHF-4
• UniProt Entry Name: FGF14_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cytokine

Chromosomal Location of Human Ortholog: 13q34

Molecular Function: protein binding

Biological Process: cell-cell signaling; signal transduction

Disease: Spinocerebellar Ataxia 27