Rabbit anti-Human VSIG4  Monoclonal Antibody | anti-VSIG4  antibody

Rabbit anti Human VSIG4  Monoclonal Antibody

Cat. Num. AAA2544345

• Gene Names: VSIG4; CRIg; Z39IG
• Reactivity: Human
• Applications: ELISA
• Synonyms: VSIG4 ; Monoclonal Antibody; Rabbit anti Human VSIG4 Monoclonal Antibody; anti-VSIG4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 347

• Applicable Applications for anti-VSIG4 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human VSIG4. The detection limit for Human VSIG4 is approximately 0.0012 ng/well.
• Immunogen: Recombinant Human VSIG4 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-VSIG4  antibody

VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I  transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 280 amino acid precursor that contains a signal sequence, an V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 383872567
• NCBI GeneID: 11326
• NCBI GenBank Nucleotide #: NM_001257403.1
• Molecular Weight: 33,857 Da
• NCBI Official Full Name: V-set and immunoglobulin domain-containing protein 4 isoform 5
• NCBI Official Synonym Full Names: V-set and immunoglobulin domain containing 4
• NCBI Official Symbol: VSIG4
• NCBI Official Synonym Symbols: CRIg; Z39IG
• NCBI Protein Information: V-set and immunoglobulin domain-containing protein 4
• UniProt Protein Name: V-set and immunoglobulin domain-containing protein 4
• UniProt Gene Name: VSIG4
• UniProt Synonym Gene Names: CRIg; Z39IG
• UniProt Entry Name: VSIG4_HUMAN

NCBI Description

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xq12-q13.3