Rabbit anti-Human PTX3  Monoclonal Antibody | anti-PTX3  antibody

Rabbit anti Human PTX3  Monoclonal Antibody

Cat. Num. AAA2544334

• Gene Names: PTX3; TSG-14; TNFAIP5
• Reactivity: Human
• Applications: ELISA
• Synonyms: PTX3 ; Monoclonal Antibody; Rabbit anti Human PTX3 Monoclonal Antibody; anti-PTX3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 381

• Applicable Applications for anti-PTX3 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human PTX3. The detection limit for Human PTX3 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Human PTX3/Pentraxin 3/TSG-14 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PTX3  antibody

Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

NCBI and Uniprot Product Information

• NCBI GI #: 167900484
• NCBI GeneID: 5806
• NCBI GenBank Nucleotide #: NM_002852.3
• Molecular Weight: 41,976 Da
• NCBI Official Full Name: pentraxin-related protein PTX3
• NCBI Official Synonym Full Names: pentraxin 3
• NCBI Official Symbol: PTX3
• NCBI Official Synonym Symbols: TSG-14; TNFAIP5
• NCBI Protein Information: pentraxin-related protein PTX3
• UniProt Protein Name: Pentraxin-related protein PTX3
• UniProt Gene Name: PTX3
• UniProt Synonym Gene Names: TNFAIP5; TSG14; TNF alpha-induced protein 5; TSG-14
• UniProt Entry Name: PTX3_HUMAN

NCBI Description

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

Uniprot Description

PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: extracellular region; extracellular space

Molecular Function: complement component C1q binding; identical protein binding; protein binding; virion binding

Biological Process: inflammatory response; innate immune response; negative regulation of virion penetration into host cell