Mouse anti-Human SerpinA7 Monoclonal Antibody | anti-SerpinA7 antibody

Mouse anti Human SerpinA7 Monoclonal Antibody

Cat. Num. AAA2543539

• Gene Names: SERPINA7; TBG; TBGQTL
• Reactivity: Human
• Applications: ELISA
• Synonyms: SerpinA7; Monoclonal Antibody; Mouse anti Human SerpinA7 Monoclonal Antibody; anti-SerpinA7 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1

• Applicable Applications for anti-SerpinA7 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human SerpinA7 protein
• Buffer: PBS with 0.05% sodium azide, 30% glycerol and 5% trehalose
• Produce: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Serpin A7. The IgG fraction of the cell culture supertanant was purified by protein A affinity chromatography.
• Preparation and Storage: Store at -20°C, Avoid freeze/thaw cycles

Related Product Information for anti-SerpinA7 antibody

Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

NCBI and Uniprot Product Information

• NCBI GI #: 823672780
• NCBI GeneID: 6906
• NCBI Official Full Name: SERPINA7, partial
• NCBI Official Synonym Full Names: serpin family A member 7
• NCBI Official Symbol: SERPINA7
• NCBI Official Synonym Symbols: TBG; TBGQTL
• NCBI Protein Information: thyroxine-binding globulin
• UniProt Protein Name: Thyroxine-binding globulin
• Protein Family: Thyroxine-binding globulin
• UniProt Gene Name: SERPINA7
• UniProt Synonym Gene Names: TBG
• UniProt Entry Name: THBG_HUMAN

NCBI Description

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

Uniprot Description

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq22.2

Molecular Function: serine-type endopeptidase inhibitor activity

Disease: Thyroxine-binding Globulin Quantitative Trait Locus