Mouse anti-Human CSF2RA/GM-CSFR/CD116 Monoclonal Antibody | anti-CSF2RA/GM-CSFR/CD116 antibody

Mouse anti Human CSF2RA/GM-CSFR/CD116 Monoclonal Antibody

Cat. Num. AAA2543450

• Gene Names: Csf2ra; CD116; Csfgmra; GM-CSFR; GM-CSF-Ra
• Reactivity: Human
• Applications: ELISA
• Synonyms: CSF2RA/GM-CSFR/CD116; Monoclonal Antibody; Mouse anti Human CSF2RA/GM-CSFR/CD116 Monoclonal Antibody; anti-CSF2RA/GM-CSFR/CD116 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 388

• Applicable Applications for anti-CSF2RA/GM-CSFR/CD116 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect Human CD116. The detection limit for Human CD116 is 0.16 ng/well.
• Immunogen: Recombinant Human CD116 protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD116/GM-CSFR (rh CD116; NP_034100.2; Met 1-Gly 320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 187956515
• NCBI GeneID: 12982
• Molecular Weight: 41,769 Da
• NCBI Official Full Name: Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
• NCBI Official Synonym Full Names: colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
• NCBI Official Symbol: Csf2ra
• NCBI Official Synonym Symbols: CD116; Csfgmra; GM-CSFR; GM-CSF-Ra
• NCBI Protein Information: granulocyte-macrophage colony-stimulating factor receptor subunit alpha
• UniProt Protein Name: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
• UniProt Gene Name: Csf2ra
• UniProt Synonym Gene Names: Csfgmra; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha
• UniProt Entry Name: CSF2R_MOUSE

Uniprot Description

CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: plasma membrane

Molecular Function: granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4