Mouse anti-Human DLL4/Delta-4 Monoclonal Antibody | anti-DLL4/Delta-4 antibody

Mouse anti Human DLL4/Delta-4 Monoclonal Antibody

Cat. Num. AAA2543268

• Gene Names: DLL4; AOS6; hdelta2
• Reactivity: Human
• Applications: ELISA
• Synonyms: DLL4/Delta-4; Monoclonal Antibody; Mouse anti Human DLL4/Delta-4 Monoclonal Antibody; anti-DLL4/Delta-4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 685

• Applicable Applications for anti-DLL4/Delta-4 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1.0 mug/mL. This antibody can be used at 0.5-1.0 mug/mL with the appropriate secondary reagents to detect Human DLL4. The detection limit for Human DLL4 is 0.039 ng/well.
• Immunogen: Recombinant Human DLL4 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 9506545
• NCBI GeneID: 54567
• NCBI GenBank Nucleotide #: NM_019074.3
• Molecular Weight: 74,605 Da
• NCBI Official Full Name: delta-like protein 4
• NCBI Official Synonym Full Names: delta like canonical Notch ligand 4
• NCBI Official Symbol: DLL4
• NCBI Official Synonym Symbols: AOS6; hdelta2
• NCBI Protein Information: delta-like protein 4
• UniProt Protein Name: Delta-like protein 4
• UniProt Gene Name: DLL4
• UniProt Synonym Gene Names: Delta4
• UniProt Entry Name: DLL4_HUMAN

NCBI Description

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

Uniprot Description

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: angiogenesis; blood circulation; blood vessel remodeling; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch receptor processing; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; signal transduction; T cell differentiation

Disease: Adams-oliver Syndrome 6