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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using USP28 Polyclonal Antibody at dilution 1:35)

Rabbit USP28 Polyclonal Antibody | anti-USP28 antibody

USP28 Polyclonal Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
USP28; Polyclonal Antibody; USP28 Polyclonal Antibody; anti-USP28 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Concentration
2.3mg/ml (varies by lot)
Sequence Length
1139
Applicable Applications for anti-USP28 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:2000-5000
IHC: 1:25-100
Immunogen
Synthetic peptide of human USP28
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79312
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using USP28 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using USP28 Polyclonal Antibody at dilution 1:35)
Related Product Information for anti-USP28 antibody
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66,243 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 28 isoform c
NCBI Official Synonym Full Names
ubiquitin specific peptidase 28
NCBI Official Symbol
USP28
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 28
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 28
UniProt Gene Name
USP28
UniProt Synonym Gene Names
KIAA1515
UniProt Entry Name
UBP28_HUMAN

NCBI Description

The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]

Uniprot Description

USP28: a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: protein binding; ubiquitin-specific protease activity

Biological Process: cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein deubiquitination; Ras protein signal transduction; regulation of protein stability; response to DNA damage stimulus; response to ionizing radiation

Research Articles on USP28

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Product Notes

The USP28 usp28 (Catalog #AAA2542941) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The USP28 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's USP28 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:25-100. Researchers should empirically determine the suitability of the USP28 usp28 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP28, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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