Western Blot (WB)
(Western Blot analysis of Human heart tissue using RENALASE Monoclonal Antibody at dilution of 1:2000)
Mouse anti-Human RNLS Monoclonal Antibody | anti-RNLS antibody
RNLS Monoclonal Antibody
Gene Names
RNLS; C10orf59; RENALASE
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Protein G purification
Synonyms
RNLS; Monoclonal Antibody; RNLS Monoclonal Antibody; 6530404N21Rik; AI452315; AW060440; C10orf59; Chromosome 10 open reading frame 59; FLJ11218; HGNC:25641; Hypothetical protein LOC55328; MAO C; MAO-C; mMAO C; Monoamine oxidase C; Monoamine oxidase-C; Renalase; Renalase FAD dependent amine oxidase; anti-RNLS antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
777
Purity/Purification
Protein G purification
Concentration
1mg/mL (varies by lot)
Sequence Length
342
Applicable Applications for anti-RNLS antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
WB: 1:1000-1:10000
IHC: 1:20-1:200
IHC: 1:20-1:200
Immunogen
Fusion protein of RENALASE
Buffer
PBS with 0.1% sodium azide, 50% glycerol, PH7.3
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Western Blot (WB)
(Western Blot analysis of Human heart tissue using RENALASE Monoclonal Antibody at dilution of 1:2000)
Western Blot (WB)
(Western Blot analysis of Human heart tissue using RENALASE Monoclonal Antibody at dilution of 1:2000)
Related Product Information for anti-RNLS antibody
RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. This antibody is specific to RNLS.
Product Categories/Family for anti-RNLS antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated: 38kDa
Observed: 38kDa
Observed: 38kDa
NCBI Official Full Name
renalase isoform 1
NCBI Official Synonym Full Names
renalase, FAD dependent amine oxidase
NCBI Official Symbol
RNLS
NCBI Official Synonym Symbols
C10orf59; RENALASE
NCBI Protein Information
renalase
UniProt Protein Name
Renalase
UniProt Gene Name
RNLS
UniProt Synonym Gene Names
C10orf59; MAO-C
NCBI Description
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
Uniprot Description
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Research Articles on RNLS
Similar Products
Product Notes
The RNLS rnls (Catalog #AAA2542049) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The RNLS Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RNLS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:1000-1:10000 IHC: 1:20-1:200. Researchers should empirically determine the suitability of the RNLS rnls for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNLS, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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