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Western Blot (WB) (Western Blot analysis of various cells with MRE11 Polyclonal Antibody.)

Rabbit MRE11 Polyclonal Antibody | anti-MRE11 antibody

MRE11 Polyclonal Antibody

Gene Names
Mre11a; Mre11
Reactivity
Human, Mouse, Rat, Monkey
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Antigen Affinity Purified
Synonyms
MRE11; Polyclonal Antibody; MRE11 Polyclonal Antibody; MRE11A; HNGS1; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A; anti-MRE11 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
706
Applicable Applications for anti-MRE11 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
Immunogen
Synthesized peptide derived from human MRE11 around the non-phosphorylation site of S264.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of various cells with MRE11 Polyclonal Antibody.)

Western Blot (WB) (Western Blot analysis of various cells with MRE11 Polyclonal Antibody.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
Calculated MW: 81
Observed MW: 80
NCBI Official Full Name
MRE11
NCBI Official Synonym Full Names
MRE11 homolog A, double strand break repair nuclease
NCBI Official Symbol
Mre11a
NCBI Official Synonym Symbols
Mre11
NCBI Protein Information
double-strand break repair protein MRE11A
UniProt Protein Name
Double-strand break repair protein MRE11A
UniProt Gene Name
Mre11a
UniProt Synonym Gene Names
Mre11; MRE11 homolog 1; MRE11 homolog A
UniProt Entry Name
MRE11_RAT

NCBI Description

may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]

Uniprot Description

MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: Deoxyribonuclease; DNA repair, damage; Cell cycle regulation; DNA-binding

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; endodeoxyribonuclease activity; endonuclease activity; manganese ion binding; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: cell proliferation; chromosome organization and biogenesis; DNA duplex unwinding; double-strand break repair; double-strand break repair via nonhomologous end joining; heart development; intra-S DNA damage checkpoint; meiotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomeric 3' overhang formation

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Product Notes

The MRE11 mre11a (Catalog #AAA2537227) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MRE11 Polyclonal Antibody reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's MRE11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the MRE11 mre11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRE11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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