Rabbit KLC1 Polyclonal Antibody | anti-KLC1 antibody

KLC1 Polyclonal Antibody

Cat. Num. AAA2530208

• Gene Names: KLC1; KLC; KNS2; KNS2A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: KLC1; Polyclonal Antibody; KLC1 Polyclonal Antibody; KLC; KNS2; KNS2A; anti-KLC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2mg/mL (varies by lot)
• Sequence Length: 618

• Applicable Applications for anti-KLC1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human KLC1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Lovo cell using KLC1 Polyclonal Antibody at dilution of 1:500)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer using KLC1 Polyclonal Antibody at dilution of 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain using KLC1 Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-KLC1 antibody

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 194306559
• NCBI GeneID: 3831
• NCBI Accession #: NP_001123579.1
• NCBI GenBank Nucleotide #: NM_001130107.1
• Molecular Weight: 69,765 Da
• NCBI Official Full Name: kinesin light chain 1 isoform 3
• NCBI Official Synonym Full Names: kinesin light chain 1
• NCBI Official Symbol: KLC1
• NCBI Official Synonym Symbols: KLC; KNS2; KNS2A
• NCBI Protein Information: kinesin light chain 1; kinesin 2 60/70kDa; medulloblastoma antigen MU-MB-2.50
• UniProt Protein Name: Kinesin light chain 1
• Protein Family: Kinesin
• UniProt Gene Name: KLC1
• UniProt Synonym Gene Names: KLC; KNS2; KLC 1
• UniProt Entry Name: KLC1_HUMAN

NCBI Description

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

KLC1: a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: ciliary rootlet; microtubule; kinesin complex; growth cone; cell soma; membrane; axon; cytoplasmic membrane-bound vesicle; cytosol

Molecular Function: tubulin binding; protein binding; motor activity; microtubule motor activity

Biological Process: intracellular protein transport; viral reproduction; metabolic process; axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; microtubule-based movement