Rabbit ROR1 Polyclonal Antibody | anti-ROR1 antibody

ROR1 Polyclonal Antibody

Cat. Num. AAA2528045

• Gene Names: Ror1; mRor1; Ntrkr1; 2810404D04Rik
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ROR1; Polyclonal Antibody; ROR1 Polyclonal Antibody; NTRKR1; dJ537F10.1; anti-ROR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2mg/mL (varies by lot)
• Sequence Length: 937

• Applicable Applications for anti-ROR1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human ROR1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ROR1 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using ROR1 Polyclonal Antibody at dilution 1:35)

Related Product Information for anti-ROR1 antibody

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 4514618
• NCBI GeneID: 26563
• Molecular Weight: 104,088 Da
• NCBI Official Full Name: Ror1
• NCBI Official Synonym Full Names: receptor tyrosine kinase-like orphan receptor 1
• NCBI Official Symbol: Ror1
• NCBI Official Synonym Symbols: mRor1; Ntrkr1; 2810404D04Rik
• NCBI Protein Information: tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor related 1; neurotrophic tyrosine kinase, receptor-related 1
• UniProt Protein Name: Tyrosine-protein kinase transmembrane receptor ROR1
• Protein Family: Inactive tyrosine-protein kinase transmembrane receptor
• UniProt Gene Name: Ror1
• UniProt Synonym Gene Names: Ntrkr1; mROR1
• UniProt Entry Name: ROR1_MOUSE

NCBI Description

This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Ror family

Cellular Component: membrane; integral to plasma membrane; integral to membrane; receptor complex

Molecular Function: transferase activity; Wnt-protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; signal transduction; phosphorylation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway