Rabbit MAFF Polyclonal Antibody | anti-MAFF antibody

MAFF Polyclonal Antibody

Cat. Num. AAA2527775

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: MAFF; Polyclonal Antibody; MAFF Polyclonal Antibody; U-MAF; hMafF; anti-MAFF antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.9mg/mL (varies by lot)
• Sequence Length: 156

• Applicable Applications for anti-MAFF antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human MAFF
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using MAFF Polyclonal Antibody at dilution 1:20)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MAFF Polyclonal Antibody at dilution 1:20)

Related Product Information for anti-MAFF antibody

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 2696885
• NCBI GeneID: 17133
• Molecular Weight: 16,955 Da
• NCBI Official Full Name: mafF
• NCBI Official Synonym Full Names: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
• NCBI Official Symbol: Maff
• NCBI Protein Information: transcription factor MafF; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F; avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein F
• UniProt Protein Name: Transcription factor MafF
• Protein Family: MaFF-interacting protein
• UniProt Gene Name: Maff
• UniProt Entry Name: MAFF_MOUSE

Uniprot Description

MAFF: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response. Belongs to the bZIP family. Maf subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; in utero embryonic development; regulation of epidermal cell differentiation