Rabbit CDC5L Polyclonal Antibody | anti-CDC5L antibody

CDC5L Polyclonal Antibody

Cat. Num. AAA2525761

• Gene Names: CDC5L; CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CDC5L; Polyclonal Antibody; CDC5L Polyclonal Antibody; CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; anti-CDC5L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 802

• Applicable Applications for anti-CDC5L antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Immunogen: Recombinant protein of human CDC5L
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CDC5L Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using CDC5L Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-CDC5L antibody

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

NCBI and Uniprot Product Information

• NCBI GI #: 11067747
• NCBI GeneID: 988
• NCBI Accession #: NP_001244.1
• NCBI GenBank Nucleotide #: NM_001253.3
• Molecular Weight: 92,251 Da
• NCBI Official Full Name: cell division cycle 5-like protein
• NCBI Official Synonym Full Names: cell division cycle 5-like
• NCBI Official Symbol: CDC5L
• NCBI Official Synonym Symbols: CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1
• NCBI Protein Information: cell division cycle 5-like protein; CDC5 cell division cycle 5-like; Cdc5-related protein; dJ319D22.1 (CDC5-like protein); pombe cdc5-related protein
• UniProt Protein Name: Cell division cycle 5-like protein
• Protein Family: Cell division cycle 5-like protein
• UniProt Gene Name: CDC5L
• UniProt Synonym Gene Names: KIAA0432; PCDC5RP; Cdc5-like protein
• UniProt Entry Name: CDC5L_HUMAN

NCBI Description

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Uniprot Description

CDC5L: is a spliceosome protein that binds DNA and that also regulates transcription. Is a positive regulator of cell cycle G2/M progression. Is an essential component of non-snRNA spliceosomes and is required for the second catalytic step of pre-mRNA splicing. Binds adeno-pre-mRNA in an ATP-stimulated manner. Is part of a spliceosomal 'core' complex that includes CDC5L, SF2, PRLI, SPF27, HSP7C, PRPF19/SNEV, GCN1L. Identified in the spliceosome C complex. Has been associated with aneuploidy in aging cells and in tumorigenesis. The genomic region containing the gene for CDC5L (6p21.1) is frequently amplified in osteosarcomas.

Protein type: DNA-binding; RNA splicing; Motility/polarity/chemotaxis; Spliceosome; RNA processing; Transcription factor

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA splicing; gene expression; DNA repair