Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ARC Polyclonal Antibody at dilution 1:50)
Rabbit ARC Polyclonal Antibody | anti-ARC antibody
ARC Polyclonal Antibody
Gene Names
ARC; Arg3.1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
ARC; Polyclonal Antibody; ARC Polyclonal Antibody; Arg3.1; anti-ARC antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
2.4mg/mL (varies by lot)
Sequence Length
396
Applicable Applications for anti-ARC antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Recombinant protein of human ARC
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ARC Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ARC Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human brain tissue using ARC Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human brain tissue using ARC Polyclonal Antibody at dilution 1:50)
Related Product Information for anti-ARC antibody
Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.
Product Categories/Family for anti-ARC antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
45,316 Da
NCBI Official Full Name
activity-regulated cytoskeleton-associated protein
NCBI Official Synonym Full Names
activity-regulated cytoskeleton-associated protein
NCBI Official Symbol
ARC
NCBI Official Synonym Symbols
Arg3.1
NCBI Protein Information
activity-regulated cytoskeleton-associated protein; ARC; ARC/ARG3.1; activity-regulated gene 3.1 protein homolog
UniProt Protein Name
Activity-regulated cytoskeleton-associated protein
Protein Family
UniProt Gene Name
ARC
UniProt Synonym Gene Names
Arg3.1
UniProt Entry Name
ARC_HUMAN
Uniprot Description
ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; acrosome; dendritic spine; plasma membrane; cell junction; endosome; actin cytoskeleton
Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; cytoskeleton organization and biogenesis; endocytosis; learning; regulation of neuronal synaptic plasticity; endoderm development
Research Articles on ARC
Similar Products
Product Notes
The ARC arc (Catalog #AAA2523444) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARC Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ARC can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the ARC arc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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