Testing Data
Rabbit anti-Human CSK Polyclonal Antibody | anti-CSK antibody
CSK Antibody
IHC: 1:100-1:500
Testing Data
Testing Data
NCBI and Uniprot Product Information
Uniprot Description
CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development.
Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Csk family
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; intercellular junction; cytosol; lipid raft
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; negative regulation of phagocytosis; platelet activation; cell migration; central nervous system development; negative regulation of Golgi to plasma membrane protein transport; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; negative regulation of cell proliferation; positive regulation of MAP kinase activity; T cell costimulation; negative regulation of interleukin-6 production; oligodendrocyte differentiation; innate immune response; morphogenesis of an epithelium; brain development; cell differentiation; negative regulation of bone resorption; blood coagulation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on CSK
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Product Notes
The CSK csk (Catalog #AAA2519269) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CSK Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CSK can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:200-1:2000 IHC: 1:100-1:500. Researchers should empirically determine the suitability of the CSK csk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CSK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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