Goat ZDHHC17 Polyclonal Antibody | anti-ZDHHC17 antibody

Goat Polyclonal to Human ZDHHC17

Cat. Num. AAA248927

• Gene Names: ZDHHC17; HIP3; HYPH; HIP14; HSPC294
• Reactivity: Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: ZDHHC17; Polyclonal Antibody; Goat Polyclonal to Human ZDHHC17; Anti-ZDHHC17 Antibody (C-Terminus) IHC-plus; HIP-3; HYPH; Huntingtin yeast partner H; KIAA0946; HIP-14; HIP14; Palmitoyltransferase ZDHHC17; DHHC-17; HIP3; Human ZDHHC17; anti-ZDHHC17 antibody

• Host: Goat
• Reactivity: Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
• Clonality: Polyclonal
• Specificity: Human ZDHHC17.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 632

• Applicable Applications for anti-ZDHHC17 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:8000), IHC-P (5 ug/ml), WB (1:8000, 1 - 3 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-YDQISGSGYQLV from the C-terminus of human ZDHHC17 (NP_056151.2).
• Immunogen Type: Synthetic peptide
• Immunogen: ZDHHC17 antibody was raised against synthetic peptide C-YDQISGSGYQLV from the C-terminus of human ZDHHC17 (NP_056151.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig, Opossum, Platypus (100%); Turkey, Chicken, Xenopus, Stickleback, Pufferfish, Zebrafish (92%); Lizard (83%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ZDHHC17 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Antibody (1 ug/ml) staining of Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 103471993
• NCBI GeneID: 23390
• NCBI Accession #: NP_056151.2
• NCBI GenBank Nucleotide #: NM_015336.2
• UniProt Accession #: Q8IUH5; O75407; Q7Z2I0; Q86W89; Q86YK0; Q9P088; Q9UPZ8; B4DR39
• Molecular Weight: 22,845 Da
• NCBI Official Full Name: palmitoyltransferase ZDHHC17
• NCBI Official Synonym Full Names: zinc finger, DHHC-type containing 17
• NCBI Official Symbol: ZDHHC17
• NCBI Official Synonym Symbols: HIP3; HYPH; HIP14; HSPC294
• NCBI Protein Information: palmitoyltransferase ZDHHC17; HIP-3; HIP-14; DHHC-17; huntingtin yeast partner H; Huntingtin interacting protein H; huntingtin interacting protein 3; huntingtin-interacting protein 3; huntingtin-interacting protein H; huntingtin interacting protein 14; huntingtin-interacting protein 14; putative MAPK-activating protein PM11; zinc finger, DHHC domain containing 17; putative NF-kappa-B-activating protein 205; zinc finger DHHC domain-containing protein 17
• UniProt Protein Name: Palmitoyltransferase ZDHHC17
• Protein Family: Palmitoyltransferase
• UniProt Gene Name: ZDHHC17
• UniProt Synonym Gene Names: HIP14; HIP3; HYPH; KIAA0946; HIP-14; HIP-3; DHHC-17
• UniProt Entry Name: ZDH17_HUMAN

Uniprot Description

HIP14: a palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, PSD-95, GAD2, SYT1 and Huntingtin. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Can cause cellular transformation, and is up-regulated in a number of types of human tumors. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate, and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. Three alternatively spliced isoforms have been described.

Protein type: Transferase; EC 2.3.1.225; Tumor suppressor; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: Golgi membrane; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; integral to membrane

Molecular Function: identical protein binding; protein binding; signal transducer activity; zinc ion binding; palmitoyltransferase activity; magnesium ion transmembrane transporter activity; protein-cysteine S-palmitoleyltransferase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein palmitoylation; lipoprotein transport; signal transduction; magnesium ion transport