Rabbit anti-Human, Mouse PSG3 Polyclonal Antibody | anti-PSG3 antibody

Rabbit Polyclonal to Human PSG3

Cat. Num. AAA248686

• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: PSG3; Polyclonal Antibody; Rabbit Polyclonal to Human PSG3; Anti-PSG3 Antibody (aa29-58) IHC-plus; Carcinoembryonic antigen SG5; PSBG-3; PS-beta-G-3; Human PSG3; anti-PSG3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Human PSG3
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.09% sodium azide
• Sequence Length: 428

• Applicable Applications for anti-PSG3 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:100), WB (1:1000)
• Target Species: Human
• Immunogen Description: KLH-conjugated synthetic peptide from N-terminal region of human PSG3.
• Immunogen Type: Synthetic peptide
• Immunogen: PSG3 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human PSG3.
• Antigen Modification: aa29-58
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-PSG3 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)

Western Blot (WB)

(PSG3 Antibody (N-term) Western blot of MCF-7 cell line and mouse liver,brain tissue lysates (35 ug/lane). This demonstrates the PSG3 antibody detected the PSG3 protein (arrow).)

Product Categories/Family for anti-PSG3 antibody

Family: CEA

NCBI and Uniprot Product Information

• NCBI GI #: 109240546
• NCBI GeneID: 5671
• NCBI Accession #: NP_066296.2
• NCBI GenBank Nucleotide #: NM_021016.3
• UniProt Accession #: Q16557; Q08265; Q9BRW2; Q9UPL4; Q9UQ77
• Molecular Weight: 47,945 Da
• NCBI Official Full Name: pregnancy-specific beta-1-glycoprotein 3
• NCBI Official Synonym Full Names: pregnancy specific beta-1-glycoprotein 3
• NCBI Official Symbol: PSG3
• NCBI Protein Information: pregnancy-specific beta-1-glycoprotein 3; PSBG-3; PS-beta-G-3; carcinoembryonic antigen SG5; pregnancy-specific glycoprotein 3
• UniProt Protein Name: Pregnancy-specific beta-1-glycoprotein 3
• Protein Family: Pregnancy-specific beta-1-glycoprotein
• UniProt Gene Name: PSG3
• UniProt Synonym Gene Names: PS-beta-G-3; PSBG-3; Pregnancy-specific glycoprotein 3
• UniProt Entry Name: PSG3_HUMAN

NCBI Description

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Uniprot Description

PSG3: Belongs to the immunoglobulin superfamily. CEA family

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular region

Biological Process: defense response; female pregnancy